759 securities that are traded on U.S. exchanges
| Symbol | Description | GICS sector | Category1 | Category2 | Category3 | Market Cap | Average Volume | |
|---|---|---|---|---|---|---|---|---|
| AADI | Aadi Biosciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $277,842,532 | 115,311 | |
| ABCL | AbCellera Biologics Inc. | Health Care | US Equity | Common stocks | Mid cap | $3,809,452,270 | 1,532,720 | |
| ABCM | Abcam plc ADRs | Health Care | US Equity | ADRs | Mid cap | $3,510,242,750 | 268,390 | |
| ABEO | Abeona Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $27,371,610 | 132,178 | |
| ABIO | Arca Biopharma Inc | Health Care | US Equity | Common stocks | Micro cap | $34,582,902 | 38,775 | |
| ABOS | Acumen Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $214,251,655 | 39,777 | |
| ABSI | AbSci Corp | Health Care | US Equity | Common stocks | Small cap | $444,761,233 | 227,557 | |
| ABUS | Arbutus Biopharma Corporation | Health Care | US Equity | Common stocks | Small cap | $370,377,997 | 851,810 | |
| ABVC | American BriVision (Holding) Corporation | Health Care | US Equity | Common stocks | Micro cap | $17,275,178 | 72,740 | |
| ACAD | Acadia Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Mid cap | $2,547,411,732 | 1,533,409 | |
| ACER | Acer Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $22,657,630 | 71,842 | |
| ACET | Adicet Bio, Inc. | Health Care | US Equity | Common stocks | Small cap | $627,282,652 | 262,331 | |
| ACHL | Achilles Therapeutics plc | Health Care | US Equity | Common stocks | Micro cap | $119,813,229 | 41,369 | |
| ACHV | Achieve Life Sciences | Health Care | US Equity | Common stocks | Micro cap | $50,345,646 | 21,063 | |
| ACIU | AC Immune SA | Health Care | US Equity | Common stocks | Micro cap | $271,544,956 | 59,363 | |
| ACLX | Arcellx, Inc. | Health Care | US Equity | Common stocks | Small cap | $829,755,767 | 249,758 | |
| ACOR | Acorda Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $4,371,756 | 209,889 | |
| ACRS | Aclaris Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $1,120,085,400 | 233,098 | |
| ACST | Acasti Pharma Inc. | Health Care | US Equity | Common stocks | Micro cap | $40,044,774 | 75,525 | |
| ACXP | Acurx Pharmaceuticals, LLC | Health Care | US Equity | Common stocks | Micro cap | $46,553,884 | 8,893 | |
| ADAG | Adagene Inc. ADRs | Health Care | US Equity | ADRs | Micro cap | $63,939,354 | 37,656 | |
| ADAP | Adaptimmune Therapeutics ADRs | Health Care | US Equity | ADRs | Small cap | $364,543,191 | 196,802 | |
| ADCT | ADC Therapeutics SA | Health Care | US Equity | Common stocks | Small cap | $623,701,073 | 288,174 | |
| ADGI | Adagio Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $411,431,899 | 402,988 | |
| ADIL | Adial Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $13,621,560 | 2,264,255 | |
| ADMA | Adma Biologics Inc | Health Care | US Equity | Common stocks | Small cap | $437,876,442 | 1,496,445 | |
| ADPT | Adaptive Biotechnologies Corporation | Health Care | US Equity | Common stocks | Small cap | $1,731,620,615 | 1,222,548 | |
| ADTX | ADiTx Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $9,434,801 | 2,955,661 | |
| ADVM | Adverum Biotechnologies Inc | Health Care | US Equity | Common stocks | Micro cap | $149,143,227 | 694,122 | |
| ADXN | Addex Therapeutics Ltd ADRs | Health Care | US Equity | ADRs | Micro cap | $14,033,684 | 16,150,118 | |
| AEZS | Aeterna Zentaris Inc. | Health Care | US Equity | Common stocks | Micro cap | $24,133,724 | 142,392 | |
| AFMD | Affimed N.V. | Health Care | US Equity | Common stocks | Small cap | $371,493,514 | 571,671 | |
| AGE | Agex Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $25,418,059 | 19,896 | |
| AGEN | Agenus Inc | Health Care | US Equity | Common stocks | Small cap | $756,044,948 | 4,484,615 | |
| AGIO | Agios Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $1,424,721,094 | 537,328 | |
| AGLE | Aeglea Biotherapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $30,580,138 | 220,648 | |
| AGTC | Applied Genetic Technologies Corp | Health Care | US Equity | Common stocks | Micro cap | $21,733,547 | 1,863,237 | |
| AIKI | AIkido Pharma Inc. | Health Care | US Equity | Common stocks | Micro cap | $32,040,586 | 28,431 | |
| AIM | AIM ImmunoTech Inc. | Health Care | US Equity | Common stocks | Micro cap | $36,300,885 | 205,718 | |
| AKBA | Akebia Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $73,282,073 | 3,360,504 | |
| AKRO | Akero Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $475,278,539 | 228,806 | |
| AKTX | Akari Therapeutics PLC ADRs | Health Care | US Equity | ADRs | Micro cap | $89,023,757 | 119,094 | |
| AKUS | Akouos, Inc. | Health Care | US Equity | Common stocks | Micro cap | $97,992,021 | 113,231 | |
| ALBO | Albireo Pharma Inc | Health Care | US Equity | Common stocks | Small cap | $439,321,466 | 184,475 | |
| ALDX | Aldeyra Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $407,678,581 | 688,068 | |
| ALEC | Alector, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,054,918,833 | 398,595 | |
| ALGS | Aligos Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $59,933,075 | 68,434 | |
| ALKS | Alkermes PLC | Health Care | US Equity | Common stocks | Mid cap | $4,183,556,384 | 1,825,627 | |
| ALLK | Allakos Inc. | Health Care | US Equity | Common stocks | Micro cap | $197,438,688 | 950,662 | |
| ALLO | Allogene Therapeutics Inc | Health Care | US Equity | Common stocks | Mid cap | $2,382,879,090 | 1,240,107 | |
| ALLR | Allarity Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $11,182,318 | 159,494 | |
| ALNA | Allena Pharmaceuticals | Health Care | US Equity | Common stocks | Micro cap | $13,745,732 | 16,336,689 | |
| ALNY | Alnylam Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Large cap | $27,532,892,369 | 1,360,213 | |
| ALPN | Alpine Immune Sciences | Health Care | US Equity | Common stocks | Micro cap | $260,218,204 | 49,464 | |
| ALRN | Aileron Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $19,663,309 | 769,442 | |
| ALT | Altimmune Inc | Health Care | US Equity | Common stocks | Small cap | $595,130,560 | 1,396,747 | |
| ALVR | AlloVir, Inc. | Health Care | US Equity | Common stocks | Small cap | $619,802,584 | 824,843 | |
| ALXO | ALX Oncology Holdings Inc. | Health Care | US Equity | Common stocks | Small cap | $528,896,904 | 209,359 | |
| ALZN | Alzamend Neuro, Inc. | Health Care | US Equity | Common stocks | Micro cap | $96,436,608 | 266,011 | |
| AMAM | Ambrx Biopharma Inc. ADRs | Health Care | US Equity | ADRs | Micro cap | $89,911,552 | 11,761 | |
| AMLX | Amylyx Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,521,863,876 | 763,945 | |
| AMPE | Ampio Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $23,533,834 | 5,649,376 | |
| AMRN | Amarin Corp PLC ADRs | Health Care | US Equity | ADRs | Small cap | $639,183,126 | 2,735,762 | |
| AMTI | Applied Molecular Transport Inc. | Health Care | US Equity | Common stocks | Micro cap | $76,245,225 | 370,727 | |
| ANAB | Anaptysbio Inc | Health Care | US Equity | Common stocks | Small cap | $705,980,300 | 230,341 | |
| ANEB | Anebulo Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $105,750,889 | 6,137 | |
| ANGN | Angion Biomedica Corp. | Health Care | US Equity | Common stocks | Micro cap | $30,857,605 | 91,237 | |
| ANIK | Anika Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $317,402,630 | 66,251 | |
| ANNX | Annexon, Inc. | Health Care | US Equity | Common stocks | Micro cap | $267,611,699 | 186,612 | |
| ANPC | AnPac Bio-Medical Science Co., Ltd. ADRs of Class A | Health Care | US Equity | ADRs | Micro cap | $8,647,477 | 233,524 | |
| ANTX | AN2 Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $228,369,285 | 28,694 | |
| ANVS | Annovis Bio, Inc. | Health Care | US Equity | Common stocks | Micro cap | $99,110,025 | 34,823 | |
| APLS | Apellis Pharmaceuticals | Health Care | US Equity | Common stocks | Mid cap | $7,191,782,865 | 1,663,099 | |
| APLT | Applied Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $34,895,118 | 176,761 | |
| APM | Aptorum Group Limited - Class A | Health Care | US Equity | Common stocks | Micro cap | $20,727,781 | 82,710 | |
| APRE | Aprea Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $21,723,795 | 485,170 | |
| APTO | Aptose Biosciences Inc. | Health Care | US Equity | Common stocks | Micro cap | $77,057,036 | 153,599 | |
| APTX | Aptinyx Inc. | Health Care | US Equity | Common stocks | Micro cap | $40,629,431 | 154,711 | |
| APVO | Aptevo Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $22,031,865 | 60,769 | |
| AQST | Aquestive Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $74,157,409 | 381,516 | |
| ARAV | Aravive Inc | Health Care | US Equity | Common stocks | Micro cap | $28,238,554 | 73,910 | |
| ARCT | Arcturus Therapeutics Ltd. | Health Care | US Equity | Common stocks | Small cap | $452,595,360 | 394,851 | |
| ARDS | Aridis Pharmaceuticals Inc. | Health Care | US Equity | Common stocks | Micro cap | $40,890,678 | 326,028 | |
| ARDX | Ardelyx Inc | Health Care | US Equity | Common stocks | Micro cap | $138,275,131 | 1,286,240 | |
| ARGX | argenx SE ADRs | Health Care | US Equity | ADRs | Large cap | $20,600,710,358 | 249,278 | |
| ARMP | Armata Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $153,476,225 | 2,461 | |
| ARQT | Arcutis Biotherapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,280,297,496 | 699,191 | |
| ARTL | Artelo Biosciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $157,359,768 | 213,416 | |
| ARVN | Arvinas, Inc. | Health Care | US Equity | Common stocks | Mid cap | $2,901,817,007 | 338,929 | |
| ARWR | Arrowhead Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Mid cap | $4,829,888,182 | 735,750 | |
| ASLN | ASLAN Pharmaceuticals Limited ADRs | Health Care | US Equity | ADRs | Micro cap | $48,123,824 | 122,725 | |
| ASMB | Assembly Biosciences Inc | Health Care | US Equity | Common stocks | Micro cap | $102,201,817 | 464,545 | |
| ASND | Ascendis Pharma ADRs | Health Care | US Equity | ADRs | Mid cap | $5,970,245,704 | 391,559 | |
| ATAI | ATAI Life Sciences N.V. | Health Care | US Equity | Common stocks | Small cap | $712,046,238 | 966,025 | |
| ATHA | Athira Pharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $141,134,936 | 545,931 | |
| ATHE | Alterity Therapeutics Limited ADRs | Health Care | US Equity | ADRs | Micro cap | $24,493,960 | 104,352 | |
| ATHX | Athersys Inc | Health Care | US Equity | Common stocks | Micro cap | $74,323,746 | 32,169,043 | |
| ATNF | 180 Life Sciences Corp. | Health Care | US Equity | Common stocks | Micro cap | $36,533,891 | 147,611 | |
| ATNM | Actinium Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $135,571,684 | 95,113 | |
| ATOS | Atossa Genetics Inc | Health Care | US Equity | Common stocks | Micro cap | $132,955,316 | 775,026 | |
| ATRA | Atara Biotherapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $438,784,788 | 3,115,005 | |
| ATXI | Avenue Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $6,339,307 | 206,895 | |
| ATXS | Astria Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $70,291,557 | 96,658 | |
| AUPH | Aurinia Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $1,159,259,119 | 3,249,933 | |
| AURA | Aura Biosciences, Inc. | Health Care | US Equity | Common stocks | Small cap | $510,293,981 | 43,279 | |
| AUTL | Autolus Therapeutics plc ADRs | Health Care | US Equity | ADRs | Small cap | $314,541,092 | 125,884 | |
| AVEO | Aveo Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $269,645,272 | 182,061 | |
| AVIR | Atea Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Small cap | $685,218,303 | 296,620 | |
| AVRO | Avrobio Inc. | Health Care | US Equity | Common stocks | Micro cap | $45,524,852 | 216,868 | |
| AVTE | Aerovate Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $582,431,977 | 206,709 | |
| AVTX | Avalo Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $51,306,872 | 35,974 | |
| AVXL | Anavex Life Sciences Corp | Health Care | US Equity | Common stocks | Small cap | $856,591,537 | 841,249 | |
| AXLA | Axcella Health Inc. | Health Care | US Equity | Common stocks | Micro cap | $123,027,466 | 45,423 | |
| AXSM | Axsome Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $1,763,562,086 | 733,793 | |
| AYLA | Ayala Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $19,725,090 | 11,409,185 | |
| AYTU | Aytu Bioscience Inc. | Health Care | US Equity | Common stocks | Micro cap | $11,412,235 | 354,143 | |
| BBI | Brickell Biotech, Inc. | Health Care | US Equity | Common stocks | Small cap | $390,489,852 | 325,586 | |
| BBIO | BridgeBio Pharma, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,612,919,842 | 2,923,504 | |
| BCAB | BioAtla, Inc. | Health Care | US Equity | Common stocks | Micro cap | $288,617,929 | 381,036 | |
| BCDA | BioCardia, Inc. | Health Care | US Equity | Common stocks | Micro cap | $28,057,947 | 31,149 | |
| BCEL | Atreca, Inc. - Class A | Health Care | US Equity | Common stocks | Micro cap | $76,502,388 | 214,333 | |
| BCLI | Brainstorm Cell Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $107,634,231 | 55,293 | |
| BCRX | Biocryst Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Mid cap | $2,672,029,880 | 2,218,957 | |
| BCTX | BriaCell Therapeutics Corp. | Health Care | US Equity | Common stocks | Micro cap | $99,315,315 | 271,368 | |
| BCYC | Bicycle Therapeutics plc ADRs | Health Care | US Equity | ADRs | Small cap | $768,908,451 | 228,263 | |
| BDTX | Black Diamond Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $143,540,891 | 167,043 | |
| BEAM | Beam Therapeutics Inc. | Health Care | US Equity | Common stocks | Mid cap | $4,649,735,117 | 1,039,684 | |
| BGNE | BeiGene ADRs | Health Care | US Equity | ADRs | Large cap | $20,346,097,950 | 250,422 | |
| BHVN | Biohaven Pharmaceutical Holding Co | Health Care | US Equity | Common stocks | Large cap | $10,553,347,133 | 555,596 | |
| BIOR | Biora Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $171,305,004 | 1,313,673 | |
| BIVI | BioVie Inc. Class A | Health Care | US Equity | Common stocks | Micro cap | $51,777,613 | 45,425 | |
| BLCM | Bellicum Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $12,225,719 | 19,917 | |
| BLI | Berkeley Lights, Inc. | Health Care | US Equity | Common stocks | Small cap | $325,031,488 | 675,273 | |
| BLPH | Bellerophon Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $13,268,177 | 21,828 | |
| BLRX | BioLineRX Ltd. ADRs | Health Care | US Equity | ADRs | Micro cap | $84,278,617 | 83,909 | |
| BLTE | Belite Bio, Inc - ADRs | Health Care | US Equity | ADRs | Small cap | $765,170,144 | 103,635 | |
| BLU | BELLUS Health Inc. | Health Care | US Equity | Common stocks | Small cap | $1,427,749,597 | 1,009,681 | |
| BLUE | Bluebird Bio Inc | Health Care | US Equity | Common stocks | Small cap | $486,638,249 | 4,391,003 | |
| BMEA | Biomea Fusion, Inc. | Health Care | US Equity | Common stocks | Small cap | $336,841,820 | 97,894 | |
| BMRN | Biomarin Pharmaceutical Inc | Health Care | US Equity | Common stocks | Large cap | $17,633,000,536 | 900,131 | |
| BNOX | Bionomics Limited ADRs | Health Care | US Equity | ADRs | Micro cap | $47,517,647 | 2,052 | |
| BNTC | Benitec Biopharma | Health Care | US Equity | Common stocks | Micro cap | $7,075,049 | 79,344 | |
| BNTX | BioNTech SE ADRs | Health Care | US Equity | ADRs | Large cap | $38,540,417,465 | 986,421 | |
| BOLT | Bolt Biotherapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $88,833,843 | 125,260 | |
| BPMC | Blueprint Medicines Corp | Health Care | US Equity | Common stocks | Mid cap | $4,153,258,537 | 626,172 | |
| BPTH | Bio Path Holdings Inc | Health Care | US Equity | Common stocks | Micro cap | $29,643,079 | 28,954 | |
| BPTS | Biophytis SA ADRs | Health Care | US Equity | ADRs | Micro cap | $18,347,435 | 11,501 | |
| BRTX | BioRestorative Therapies, Inc. | Health Care | US Equity | Common stocks | Micro cap | $10,828,281 | 11,254 | |
| BTAI | Bioxcel Therapeutics Inc. | Health Care | US Equity | Common stocks | Small cap | $424,534,650 | 291,909 | |
| BTTX | Better Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $42,255,980 | 4,227,541 | |
| BTX | Brooklyn ImmunoTherapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $32,695,346 | 425,053 | |
| BVXV | BiondVax Pharmaceuticals Ltd. ADRs | Health Care | US Equity | ADRs | Micro cap | $13,851,433 | 20,776 | |
| BWV | Blue Water Vaccines, Inc. | Health Care | US Equity | Common stocks | Micro cap | $29,518,558 | 8,027,461 | |
| BXRX | Baudax Bio, Inc. | Health Care | US Equity | Common stocks | Micro cap | $4,921,120 | 131,844 | |
| BYSI | Beyondspring Inc. | Health Care | US Equity | Common stocks | Micro cap | $59,171,961 | 170,833 | |
| CABA | Cabaletta Bio, Inc. | Health Care | US Equity | Common stocks | Micro cap | $42,016,837 | 168,425 | |
| CADL | Candel Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $93,898,704 | 3,780 | |
| CALA | Calithera Biosciences Inc | Health Care | US Equity | Common stocks | Small cap | $375,331,632 | 101,485 | |
| CANF | Can-Fite BioPharma Ltd. ADRs | Health Care | US Equity | ADRs | Micro cap | $24,439,759 | 79,095 | |
| CAPR | Capricor Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $128,431,544 | 98,045 | |
| CARA | Cara Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $624,832,508 | 448,913 | |
| CASI | CASI Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Small cap | $530,643,731 | 109,246 | |
| CBAY | CymaBay Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $316,695,492 | 541,628 | |
| CBIO | Catalyst Biosciences Inc | Health Care | US Equity | Common stocks | Micro cap | $58,547,319 | 357,161 | |
| CCCC | C4 Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $565,443,123 | 393,010 | |
| CCXI | Chemocentryx Inc | Health Care | US Equity | Common stocks | Mid cap | $3,610,607,123 | 1,226,816 | |
| CDAK | Codiak BioSciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $51,895,751 | 78,376 | |
| CDMO | Avid Bioservices Inc | Health Care | US Equity | Common stocks | Small cap | $1,173,004,449 | 628,535 | |
| CDTX | Cidara Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $43,501,183 | 1,210,263 | |
| CDXC | Chromadex Corp | Health Care | US Equity | Common stocks | Micro cap | $113,449,048 | 305,730 | |
| CDXS | Codexis Inc | Health Care | US Equity | Common stocks | Small cap | $546,220,761 | 1,495,708 | |
| CELU | Celularity Inc. - Class A | Health Care | US Equity | Common stocks | Small cap | $441,212,326 | 463,992 | |
| CELZ | Creative Medical Technology Holdings, Inc. | Health Care | US Equity | Common stocks | Micro cap | $7,224,858 | 1,098,618 | |
| CERE | Cerevel Therapeutics Holdings, Inc. | Health Care | US Equity | Common stocks | Mid cap | $5,291,124,764 | 693,565 | |
| CERS | Cerus Corp | Health Care | US Equity | Common stocks | Small cap | $929,724,411 | 1,329,477 | |
| CERT | Certara, Inc. | Health Care | US Equity | Common stocks | Mid cap | $3,228,027,433 | 319,591 | |
| CFRX | ContraFect Corp | Health Care | US Equity | Common stocks | Micro cap | $11,835,216 | 2,756,361 | |
| CGEM | Cullinan Management, Inc. | Health Care | US Equity | Common stocks | Small cap | $605,273,960 | 198,167 | |
| CGEN | Compugen Ltd. | Health Care | US Equity | Common stocks | Micro cap | $126,192,811 | 781,418 | |
| CGTX | Cognition Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $53,824,444 | 265,163 | |
| CHRS | Coherus Biosciences Inc | Health Care | US Equity | Common stocks | Small cap | $983,216,051 | 1,092,372 | |
| CINC | CinCor Pharma, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,294,836,172 | 328,673 | |
| CING | Cingulate Inc. | Health Care | US Equity | Common stocks | Micro cap | $16,851,024 | 39,800 | |
| CKPT | Checkpoint Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $105,873,317 | 479,986 | |
| CLBS | Caladrius Biosciences Inc | Health Care | US Equity | Common stocks | Micro cap | $32,115,180 | 147,334 | |
| CLDX | Celldex Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $1,615,049,280 | 491,462 | |
| CLGN | CollPlant Holdings ADRs | Health Care | US Equity | ADRs | Micro cap | $104,498,955 | 43,186 | |
| CLLS | Cellectis SA ADRs | Health Care | US Equity | ADRs | Micro cap | $171,575,754 | 103,887 | |
| CLNN | Clene Inc. | Health Care | US Equity | Common stocks | Micro cap | $218,235,080 | 953,135 | |
| CLRB | Cellectar Biosciences Inc | Health Care | US Equity | Common stocks | Micro cap | $35,744,220 | 64,924 | |
| CLSD | Clearside Biomedical Inc | Health Care | US Equity | Common stocks | Micro cap | $93,233,185 | 128,860 | |
| CLSN | Celsion Corp | Health Care | US Equity | Common stocks | Micro cap | $18,669,689 | 66,936 | |
| CLVS | Clovis Oncology Inc | Health Care | US Equity | Common stocks | Micro cap | $209,496,312 | 4,568,346 | |
| CMMB | Chemomab Therapeutics Ltd. ADRs | Health Care | US Equity | ADRs | Micro cap | $42,538,841 | 40,664 | |
| CMPI | Checkmate Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $230,519,568 | 63,651 | |
| CMPX | Compass Therapeutics, Inc | Health Care | US Equity | Common stocks | Micro cap | $278,532,686 | 104,583 | |
| CMRX | Chimerix Inc | Health Care | US Equity | Common stocks | Micro cap | $209,418,619 | 9,194,377 | |
| CNCE | Concert Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $340,336,008 | 388,307 | |
| CNSP | CNS Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $10,388,429 | 363,202 | |
| CNTA | Centessa Pharmaceuticals Ltd ADRs | Health Care | US Equity | ADRs | Small cap | $402,495,604 | 186,521 | |
| CNTB | Connect Biopharma Holdings Ltd ADRs | Health Care | US Equity | ADRs | Micro cap | $87,571,347 | 728,140 | |
| CNTX | Context Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $32,411,088 | 291,854 | |
| COCP | Cocrystal Pharma Inc. | Health Care | US Equity | Common stocks | Micro cap | $41,395,084 | 153,859 | |
| COGT | Cogent Biosciences, Inc. | Health Care | US Equity | Common stocks | Small cap | $884,448,678 | 627,605 | |
| CORT | Corcept Therapeutics Inc | Health Care | US Equity | Common stocks | Mid cap | $2,995,729,032 | 637,117 | |
| CPRX | Catalyst Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $1,374,696,768 | 2,391,302 | |
| CRBP | Corbus Pharmaceuticals Holdings Inc | Health Care | US Equity | Common stocks | Micro cap | $33,120,960 | 397,528 | |
| CRBU | Caribou Biosciences, Inc. | Health Care | US Equity | Common stocks | Small cap | $571,291,788 | 461,629 | |
| CRDF | Cardiff Oncology, Inc. | Health Care | US Equity | Common stocks | Micro cap | $130,784,304 | 468,658 | |
| CRIS | Curis Inc | Health Care | US Equity | Common stocks | Micro cap | $98,060,545 | 1,415,925 | |
| CRMD | Cormedix Inc | Health Care | US Equity | Common stocks | Micro cap | $145,538,523 | 507,048 | |
| CRNX | Crinetics Pharmaceuticals Inc. | Health Care | US Equity | Common stocks | Small cap | $1,101,684,607 | 223,067 | |
| CRSP | CRISPR Therapeutics AG | Health Care | US Equity | Common stocks | Mid cap | $6,042,597,280 | 1,402,277 | |
| CRTX | Cortexyme, Inc. | Health Care | US Equity | Common stocks | Micro cap | $58,794,128 | 313,139 | |
| CRVS | Corvus Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $44,924,138 | 312,596 | |
| CSBR | Champions Oncology Inc. | Health Care | US Equity | Common stocks | Micro cap | $127,110,945 | 13,616 | |
| CTIC | CTI BioPharma Corp | Health Care | US Equity | Common stocks | Small cap | $653,140,103 | 3,198,616 | |
| CTMX | Cytomx Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $100,903,870 | 1,276,973 | |
| CTXR | Citius Pharmaceuticals Inc. | Health Care | US Equity | Common stocks | Micro cap | $173,894,260 | 700,889 | |
| CUE | Cue Biopharma Inc. | Health Care | US Equity | Common stocks | Micro cap | $117,113,569 | 164,576 | |
| CVAC | CureVac N.V. | Health Care | US Equity | Common stocks | Mid cap | $2,505,546,414 | 302,964 | |
| CVM | Cel-Sci Corporation | Health Care | US Equity | Common stocks | Micro cap | $173,312,416 | 309,673 | |
| CWBR | Cohbar Inc. | Health Care | US Equity | Common stocks | Micro cap | $17,135,392 | 223,251 | |
| CYAD | Celyad SA ADRs | Health Care | US Equity | ADRs | Micro cap | $46,543,549 | 22,541 | |
| CYBN | Cybin Inc. | Health Care | US Equity | Common stocks | Micro cap | $142,298,538 | 973,973 | |
| CYCC | Cyclacel Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $16,791,582 | 1,538,427 | |
| CYCN | Cyclerion Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $42,579,393 | 145,822 | |
| CYT | Cyteir Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $88,887,699 | 60,793 | |
| CYTH | Cyclo Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $19,358,070 | 30,495 | |
| CYTK | Cytokinetics Inc | Health Care | US Equity | Common stocks | Mid cap | $4,657,308,479 | 1,333,690 | |
| CYTO | Altamira Therapeutics Ltd. | Health Care | US Equity | Common stocks | Micro cap | $6,889,546 | 5,151,135 | |
| DARE | Dare Bioscience Inc | Health Care | US Equity | Common stocks | Micro cap | $100,088,612 | 508,069 | |
| DAWN | Day One Biopharmaceuticals Holding Co LLC | Health Care | US Equity | Common stocks | Small cap | $1,799,796,950 | 378,979 | |
| DBTX | Decibel Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $108,096,294 | 79,571 | |
| DBVT | DBV Technologies S.A. ADRs | Health Care | US Equity | ADRs | Small cap | $502,064,552 | 96,208 | |
| DCPH | Deciphera Pharmaceuticals | Health Care | US Equity | Common stocks | Small cap | $1,053,784,296 | 649,261 | |
| DFFN | Diffusion Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $14,169,021 | 26,651 | |
| DICE | DICE Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $786,376,187 | 273,005 | |
| DMAC | Diamedica Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $50,241,827 | 107,650 | |
| DNA | Ginkgo Bioworks Holdings, Inc. Class A | Materials | US Equity | Common stocks | Mid cap | $3,717,977,217 | 24,405,309 | |
| DNLI | Denali Therapeutics Inc. | Health Care | US Equity | Common stocks | Mid cap | $4,746,437,505 | 570,387 | |
| DRMA | Dermata Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $5,671,968 | 847,820 | |
| DRTS | Alpha Tau Medical Ltd. - Class A | Health Care | US Equity | Common stocks | Small cap | $723,158,473 | 21,138 | |
| DRUG | Bright Minds Biosciences Inc. | Health Care | US Equity | Common stocks | Micro cap | $12,111,861 | 166,532 | |
| DSGN | Design Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,285,256,743 | 105,222 | |
| DTIL | Precision BioSciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $180,633,353 | 1,902,298 | |
| DVAX | Dynavax Technologies Corp | Health Care | US Equity | Common stocks | Mid cap | $2,110,844,150 | 1,572,461 | |
| DYAI | Dyadic International, Inc. | Health Care | US Equity | Common stocks | Micro cap | $75,036,984 | 45,120 | |
| DYN | Dyne Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $611,349,020 | 181,132 | |
| EDIT | Editas Medicine Inc | Health Care | US Equity | Common stocks | Small cap | $1,243,456,853 | 1,768,420 | |
| EDSA | Edesa Biotech, Inc. | Health Care | US Equity | Common stocks | Micro cap | $31,388,443 | 72,599 | |
| EFTR | eFFECTOR Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $31,270,049 | 144,977 | |
| EIGR | Eiger Biopharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $392,623,372 | 209,251 | |
| ELDN | Eledon Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $47,736,054 | 37,750 | |
| ELEV | Elevation Oncology, Inc. | Health Care | US Equity | Common stocks | Micro cap | $29,344,221 | 92,826 | |
| ELOX | Eloxx Pharmaceuticals Inc. | Health Care | US Equity | Common stocks | Micro cap | $23,786,273 | 137,004 | |
| ELYM | Eliem Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $78,108,982 | 59,088 | |
| ENLV | Enlivex Therapeutics Ltd. | Health Care | US Equity | Common stocks | Micro cap | $93,191,934 | 68,910 | |
| ENOB | Enochian Biosciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $141,376,412 | 99,240 | |
| ENSC | Ensysce Biosciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $18,344,280 | 279,754 | |
| ENTA | Enanta Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $1,377,996,473 | 191,439 | |
| ENTX | Entera Bio Ltd | Health Care | US Equity | Common stocks | Micro cap | $55,026,951 | 48,823 | |
| ENVB | Enveric Biosciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $10,536,412 | 732,532 | |
| EPIX | Essa Pharma Inc. | Health Care | US Equity | Common stocks | Micro cap | $92,666,148 | 373,160 | |
| EPZM | Epizyme Inc | Health Care | US Equity | Common stocks | Micro cap | $247,496,185 | 2,174,224 | |
| EQ | Equillium, Inc. | Health Care | US Equity | Common stocks | Micro cap | $93,915,961 | 18,587 | |
| EQRX | EQRx, Inc. | Health Care | US Equity | Common stocks | Mid cap | $2,301,625,943 | 1,328,162 | |
| ERAS | Erasca, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,032,134,761 | 304,843 | |
| ERYP | Erytech Pharma S.A. ADRs | Health Care | US Equity | ADRs | Micro cap | $37,532,449 | 8,231 | |
| ESPR | Esperion Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $441,902,491 | 592,344 | |
| ETNB | 89bio, Inc. | Health Care | US Equity | Common stocks | Micro cap | $83,033,647 | 364,755 | |
| ETON | Eton Pharmaceutcials, Inc. | Health Care | US Equity | Common stocks | Micro cap | $75,925,601 | 671,046 | |
| ETTX | Entasis Therapeutics Holdings Inc. | Health Care | US Equity | Common stocks | Micro cap | $86,133,240 | 39,735 | |
| EVAX | Evaxion Biotech A/S ADRs | Health Care | US Equity | ADRs | Micro cap | $64,970,662 | 55,682 | |
| EVFM | Evofem Biosciences Inc | Health Care | US Equity | Common stocks | Micro cap | $5,150,157 | 21,429,319 | |
| EVGN | Evogene Ltd. | Health Care | US Equity | Common stocks | Micro cap | $41,600,163 | 120,746 | |
| EVLO | Evelo Biosciences Inc | Health Care | US Equity | Common stocks | Micro cap | $155,076,993 | 62,779 | |
| EWTX | Edgewise Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $495,505,990 | 198,651 | |
| EXAI | Exscientia Ltd ADRs | Health Care | US Equity | ADRs | Small cap | $1,361,764,450 | 105,248 | |
| EXEL | Exelixis Inc | Health Care | US Equity | Common stocks | Mid cap | $6,188,825,206 | 1,805,393 | |
| EYEN | Eyenovia Inc. | Health Care | US Equity | Common stocks | Micro cap | $55,723,800 | 153,695 | |
| EYPT | Eyepoint Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $377,857,360 | 228,271 | |
| FATE | Fate Therapeutics Inc | Health Care | US Equity | Common stocks | Mid cap | $3,167,059,599 | 1,156,455 | |
| FBIO | Fortress Biotech Inc | Health Care | US Equity | Common stocks | Micro cap | $138,562,926 | 331,464 | |
| FBRX | Forte Biosciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $19,042,027 | 323,992 | |
| FDMT | 4D Molecular Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $335,917,754 | 148,363 | |
| FENC | Fennec Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $183,640,514 | 37,955 | |
| FGEN | Fibrogen Inc | Health Care | US Equity | Common stocks | Small cap | $1,317,063,579 | 692,868 | |
| FHTX | Foghorn Therapeutics Inc. | Health Care | US Equity | Common stocks | Small cap | $705,337,675 | 59,834 | |
| FIXX | Homology Medicines Inc. | Health Care | US Equity | Common stocks | Micro cap | $163,548,897 | 198,606 | |
| FMTX | Forma Therapeutics Holdings, Inc. | Health Care | US Equity | Common stocks | Small cap | $535,948,638 | 385,347 | |
| FNCH | Finch Therapeutics Group, Inc. | Health Care | US Equity | Common stocks | Micro cap | $124,604,837 | 36,547 | |
| FOLD | Amicus Therapeutics Inc | Health Care | US Equity | Common stocks | Mid cap | $3,382,811,440 | 3,088,119 | |
| FREQ | Frequency Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $69,113,585 | 226,514 | |
| FRLN | Freeline Therapeutics Holdings plc ADRs | Health Care | US Equity | Common stocks | Micro cap | $59,839,031 | 156,349 | |
| FSTX | F-star Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $141,835,170 | 209,020 | |
| FULC | Fulcrum Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $309,220,965 | 371,179 | |
| FUSN | Fusion Pharmaceuticals Inc. | Health Care | US Equity | Common stocks | Micro cap | $86,781,064 | 44,719 | |
| FWBI | First Wave BioPharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $6,924,786 | 2,828,362 | |
| FWP | Forward Pharma ADRs | Health Care | US Equity | ADRs | Micro cap | $26,591,944 | 5,695 | |
| GALT | Galectin Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $120,558,692 | 145,484 | |
| GANX | Gain Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $47,652,306 | 45,142 | |
| GBIO | Generation Bio Co. | Health Care | US Equity | Common stocks | Small cap | $426,061,030 | 346,002 | |
| GBT | Global Blood Therapeutics Inc | Health Care | US Equity | Common stocks | Mid cap | $4,491,058,775 | 4,221,089 | |
| GERN | Geron Corp | Health Care | US Equity | Common stocks | Small cap | $773,766,569 | 2,550,788 | |
| GHRS | GH Research PLC | Health Care | US Equity | Common stocks | Small cap | $655,462,697 | 23,144 | |
| GLMD | Galmed Pharmaceuticals Ltd. | Health Care | US Equity | Common stocks | Micro cap | $11,028,867 | 105,268 | |
| GLPG | Galapagos NV ADRs | Health Care | US Equity | ADRs | Mid cap | $3,560,513,441 | 241,764 | |
| GLS | Gelesis Holdings, Inc. | Health Care | US Equity | Common stocks | Micro cap | $117,272,469 | 67,166 | |
| GLSI | Greenwich LifeSciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $126,103,463 | 107,689 | |
| GLTO | Galecto Inc. | Health Care | US Equity | Common stocks | Micro cap | $54,346,792 | 36,918 | |
| GLUE | Monte Rosa Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $427,482,746 | 118,306 | |
| GLYC | Glycomimetics Inc | Health Care | US Equity | Common stocks | Micro cap | $44,492,201 | 111,944 | |
| GMAB | Genmab A/S ADRs | Health Care | US Equity | ADRs | Large cap | $24,793,191,995 | 633,453 | |
| GMDA | Gamida Cell Ltd. | Health Care | US Equity | Common stocks | Micro cap | $203,348,323 | 409,498 | |
| GMTX | Gemini Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $83,428,417 | 75,874 | |
| GMVD | G Medical Innovations Holdings Ltd. | Health Care | US Equity | Common stocks | Micro cap | $9,730,514 | 1,632,463 | |
| GNCA | Genocea Biosciences Inc | Health Care | US Equity | Common stocks | Micro cap | $12,279,873 | 497,432 | |
| GNFT | GENFIT S.A. ADRs | Health Care | US Equity | ADRs | Micro cap | $235,378,186 | 48,572 | |
| GNPX | Genprex Inc. | Health Care | US Equity | Common stocks | Micro cap | $71,847,527 | 92,728 | |
| GNTA | Genenta Science S.p.A. ADRs | Health Care | US Equity | Common stocks | Micro cap | $117,498,734 | 4,783 | |
| GOSS | Gossamer Bio, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,244,891,123 | 1,559,014 | |
| GOVX | GeoVax Labs, Inc. | Health Care | US Equity | Common stocks | Micro cap | $33,879,138 | 71,508,169 | |
| GRAY | Graybug Vision, Inc. | Health Care | US Equity | Common stocks | Micro cap | $21,358,500 | 83,376 | |
| GRCL | Gracell Biotechnologies Inc. ADRs | Health Care | US Equity | ADRs | Micro cap | $229,855,881 | 76,143 | |
| GRNA | GreenLight Biosciences Holdings, PBC | Health Care | US Equity | Common stocks | Small cap | $492,796,808 | 279,153 | |
| GRPH | Graphite Bio, Inc. | Health Care | US Equity | Common stocks | Micro cap | $230,141,337 | 247,483 | |
| GRTS | Gritstone Oncology Inc. | Health Care | US Equity | Common stocks | Micro cap | $258,485,557 | 493,481 | |
| GRTX | Galera Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $36,477,361 | 58,173 | |
| GTBP | GT Biopharma Inc | Health Care | US Equity | Common stocks | Micro cap | $79,301,864 | 104,799 | |
| GTHX | G1 Therapeutics Inc. | Health Care | US Equity | Common stocks | Small cap | $515,953,948 | 1,207,130 | |
| HALO | Halozyme Therapeutics Inc | Health Care | US Equity | Common stocks | Mid cap | $5,974,113,483 | 950,365 | |
| HARP | Harpoon Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $66,213,536 | 115,809 | |
| HCM | Hutchison China Meditech ADRs | Health Care | US Equity | ADRs | Mid cap | $2,396,602,842 | 293,937 | |
| HCWB | HCW Biologics Inc. | Health Care | US Equity | Common stocks | Micro cap | $76,246,453 | 4,131 | |
| HEPA | Hepion Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $55,998,277 | 174,419 | |
| HGEN | Humanigen Inc | Health Care | US Equity | Common stocks | Micro cap | $26,212,168 | 14,542,520 | |
| HILS | Hillstream BioPharma Inc. | Health Care | US Equity | Common stocks | Micro cap | $12,417,318 | 185,235 | |
| HLVX | HilleVax, Inc. | Health Care | US Equity | Common stocks | Small cap | $411,488,943 | 61,764 | |
| HOOK | HOOKIPA Pharma Inc. | Health Care | US Equity | Common stocks | Micro cap | $80,906,826 | 326,301 | |
| HOTH | Hoth Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $14,630,044 | 495,648 | |
| HOWL | Werewolf Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $150,715,652 | 46,224 | |
| HRMY | Harmony Biosciences Holdings, Inc. | Health Care | US Equity | Common stocks | Mid cap | $3,011,906,721 | 661,112 | |
| HRTX | Heron Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $499,818,619 | 2,238,875 | |
| HSTO | Histogen Inc. | Health Care | US Equity | Common stocks | Micro cap | $5,294,594 | 476,715 | |
| HUMA | Humacyte, Inc. | Health Care | US Equity | Common stocks | Small cap | $453,220,117 | 286,299 | |
| IBIO | iBio, Inc. | Health Care | US Equity | Common stocks | Micro cap | $60,977,292 | 1,710,619 | |
| IBRX | ImmunityBio, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,769,344,149 | 1,093,737 | |
| ICCC | Immucell Corp | Health Care | US Equity | Common stocks | Micro cap | $67,750,060 | 7,142 | |
| ICPT | Intercept Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $478,854,503 | 781,912 | |
| ICVX | Icosavax, Inc. | Health Care | US Equity | Common stocks | Small cap | $334,127,357 | 75,242 | |
| IDRA | Idera Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $25,426,898 | 69,888 | |
| IDYA | IDEAYA Biosciences, Inc. | Health Care | US Equity | Common stocks | Small cap | $576,507,636 | 198,769 | |
| IFRX | InflaRx N.V. | Health Care | US Equity | Common stocks | Micro cap | $134,379,440 | 1,156,692 | |
| IGMS | IGM Biosciences, Inc. | Health Care | US Equity | Common stocks | Small cap | $718,430,258 | 162,336 | |
| IKNA | Ikena Oncology, Inc. | Health Care | US Equity | Common stocks | Micro cap | $190,218,911 | 116,525 | |
| IKT | Inhibikase Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $22,401,621 | 196,858 | |
| IMAB | I-MAB ADRs | Health Care | US Equity | ADRs | Small cap | $657,862,988 | 406,372 | |
| IMCR | Immunocore Holdings plc ADRs | Health Care | US Equity | ADRs | Mid cap | $2,305,431,396 | 190,267 | |
| IMGN | Immunogen Inc | Health Care | US Equity | Common stocks | Small cap | $1,156,536,592 | 2,642,591 | |
| IMGO | Imago BioSciences, Inc. | Health Care | US Equity | Common stocks | Small cap | $578,569,382 | 89,946 | |
| IMMP | Immutep Limited ADRs | Health Care | US Equity | ADRs | Micro cap | $195,770,199 | 42,084 | |
| IMMX | Immix Biopharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $34,157,110 | 72,581 | |
| IMNM | Immunome, Inc. | Health Care | US Equity | Common stocks | Micro cap | $62,698,580 | 20,781 | |
| IMPL | Impel NeuroPharma, Inc | Health Care | US Equity | Common stocks | Micro cap | $202,088,110 | 28,284 | |
| IMRA | IMARA Inc. | Health Care | US Equity | Common stocks | Micro cap | $29,967,481 | 56,038 | |
| IMRN | Immuron Limited ADRs | Health Care | US Equity | ADRs | Micro cap | $14,636,045 | 2,249 | |
| IMRX | Immuneering Corp | Health Care | US Equity | Common stocks | Micro cap | $167,063,253 | 26,907 | |
| IMTX | Immatics N.V. | Health Care | US Equity | Common stocks | Small cap | $719,045,492 | 391,530 | |
| IMUX | Immunic, Inc. | Health Care | US Equity | Common stocks | Micro cap | $150,379,775 | 123,796 | |
| IMV | IMV Inc. | Health Care | US Equity | Common stocks | Micro cap | $46,893,593 | 107,369 | |
| IMVT | Immunovant, Inc. | Health Care | US Equity | Common stocks | Small cap | $616,693,261 | 266,386 | |
| INAB | IN8BIO, INC. | Health Care | US Equity | Common stocks | Micro cap | $37,300,173 | 7,694 | |
| INBX | Inhibrx, Inc. | Health Care | US Equity | Common stocks | Small cap | $919,027,352 | 349,329 | |
| INCY | Incyte Corp | Health Care | US Equity | Common stocks | Large cap | $16,406,483,638 | 1,397,917 | |
| INDP | Indaptus Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $24,610,619 | 16,635 | |
| INFI | Infinity Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $96,420,103 | 283,682 | |
| INKT | MiNK Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $56,382,336 | 31,588 | |
| INM | InMed Pharmaceuticals Inc. | Health Care | US Equity | Common stocks | Micro cap | $6,462,755 | 193,845 | |
| INMB | INmune Bio Inc. | Health Care | US Equity | Common stocks | Micro cap | $163,667,474 | 55,087 | |
| INO | Inovio Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $613,525,173 | 6,229,762 | |
| INSM | Insmed Inc | Health Care | US Equity | Common stocks | Mid cap | $3,209,338,339 | 1,090,675 | |
| INVA | Innoviva Inc | Health Care | US Equity | Common stocks | Small cap | $1,008,645,342 | 682,134 | |
| INZY | Inozyme Pharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $139,136,854 | 140,737 | |
| IOBT | IO Biotech, Inc. | Health Care | US Equity | Common stocks | Micro cap | $113,243,999 | 48,557 | |
| IONS | Ionis Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Mid cap | $6,165,931,723 | 915,953 | |
| IOVA | Iovance Biotherapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $1,860,872,921 | 2,614,580 | |
| IPA | ImmunoPrecise Antibodies Ltd. | Health Care | US Equity | Common stocks | Micro cap | $130,392,796 | 16,200 | |
| IPHA | Innate Pharma S.A. ADRs | Health Care | US Equity | ADRs | Micro cap | $231,213,105 | 8,271 | |
| IPSC | Century Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $656,180,689 | 56,687 | |
| ISEE | IVERIC bio, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,538,553,916 | 2,051,054 | |
| ITCI | Intra Cellular Therapies Inc | Health Care | US Equity | Common stocks | Mid cap | $5,382,787,500 | 636,669 | |
| ITOS | iTeos Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $843,135,155 | 337,342 | |
| ITRM | Iterum Therapeutics Plc | Health Care | US Equity | Common stocks | Micro cap | $45,838,355 | 1,568,468 | |
| IVA | Inventiva S.A. ADRs | Health Care | US Equity | ADRs | Micro cap | $202,732,813 | 3,563 | |
| JAGX | Jaguar Health Inc | Health Care | US Equity | Common stocks | Micro cap | $23,068,628 | 5,547,390 | |
| JANX | Janux Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $560,784,370 | 44,197 | |
| JAZZ | Jazz Pharmaceuticals Plc | Health Care | US Equity | Common stocks | Mid cap | $9,631,763,029 | 460,613 | |
| JNCE | Jounce Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $240,378,202 | 222,514 | |
| JSPR | Jasper Therapeutics, Inc. - Class A | Health Care | US Equity | Common stocks | Micro cap | $81,208,184 | 59,149 | |
| KALA | Kala Pharmaceuticals Inc. | Health Care | US Equity | Common stocks | Micro cap | $23,810,834 | 679,191 | |
| KALV | Kalvista Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $338,095,199 | 159,894 | |
| KDNY | Chinook Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,102,993,267 | 327,841 | |
| KMPH | KemPharm, Inc. | Health Care | US Equity | Common stocks | Micro cap | $212,737,211 | 262,651 | |
| KNSA | Kiniksa Pharmaceuticals Ltd. | Health Care | US Equity | Common stocks | Small cap | $419,160,319 | 433,515 | |
| KNTE | Kinnate Biopharma Inc. | Health Care | US Equity | Common stocks | Small cap | $586,193,242 | 78,820 | |
| KOD | Kodiak Sciences Inc | Health Care | US Equity | Common stocks | Small cap | $612,513,695 | 888,798 | |
| KPRX | Kiora Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $2,378,272 | 2,267,631 | |
| KPTI | Karyopharm Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $395,840,815 | 1,907,474 | |
| KRBP | Kiromic BioPharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $6,494,036 | 185,663 | |
| KRON | Kronos Bio, Inc. | Health Care | US Equity | Common stocks | Micro cap | $277,600,855 | 177,204 | |
| KROS | Keros Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $907,318,381 | 222,341 | |
| KRTX | Karuna Therapeutics, Inc. | Health Care | US Equity | Common stocks | Mid cap | $7,827,128,703 | 600,210 | |
| KRYS | Krystal Biotech Inc | Health Care | US Equity | Common stocks | Small cap | $1,884,528,594 | 129,426 | |
| KTRA | Kintara Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $12,248,085 | 4,611,121 | |
| KTTA | Pasithea Therapeutics Corp. | Health Care | US Equity | Common stocks | Micro cap | $33,185,860 | 282,430 | |
| KURA | Kura Oncology Inc | Health Care | US Equity | Common stocks | Small cap | $1,070,288,048 | 960,076 | |
| KYMR | Kymera Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,686,064,797 | 678,065 | |
| KZIA | Kazia Therapeutics ADRs | Health Care | US Equity | ADRs | Micro cap | $24,382,531 | 126,056 | |
| KZR | Kezar Life Sciences Inc. | Health Care | US Equity | Common stocks | Small cap | $589,656,119 | 633,518 | |
| LABP | Landos Biopharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $43,475,281 | 92,955 | |
| LBPH | Longboard Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $55,702,395 | 8,483 | |
| LBPS | 4D pharma plc ADRs | Health Care | US Equity | ADRs | Micro cap | $74,599,456 | 3,914 | |
| LCTX | Lineage Cell Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $263,077,462 | 435,424 | |
| LEGN | Legend Biotech Corporation ADRs | Health Care | US Equity | ADRs | Mid cap | $7,506,717,108 | 1,269,406 | |
| LGND | Ligand Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $1,721,534,119 | 95,792 | |
| LGVN | Longeveron Inc. | Health Care | US Equity | Common stocks | Micro cap | $31,912,305 | 84,122 | |
| LIAN | LianBio ADRs | Health Care | US Equity | ADRs | Micro cap | $282,598,945 | 174,638 | |
| LIFE | Atyr Pharma Inc | Health Care | US Equity | Common stocks | Micro cap | $102,405,309 | 170,986 | |
| LIXT | Lixte Biotechnology Holdings Inc. | Health Care | US Equity | Common stocks | Micro cap | $12,484,945 | 57,420 | |
| LJPC | La Jolla Pharmaceutical | Health Care | US Equity | Common stocks | Micro cap | $154,544,108 | 179,873 | |
| LMNL | Liminal BioSciences Inc. | Health Care | US Equity | Common stocks | Micro cap | $15,636,137 | 85,719 | |
| LOGC | Logicbio Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $22,230,067 | 166,796 | |
| LPCN | Lipocine Inc | Health Care | US Equity | Common stocks | Micro cap | $62,223,086 | 184,519 | |
| LPTX | Leap Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $114,813,990 | 307,506 | |
| LQDA | Liquidia Technologies Inc. | Health Care | US Equity | Common stocks | Small cap | $367,406,958 | 4,160,636 | |
| LRMR | Larimar Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $35,066,691 | 41,897 | |
| LTRN | Lantern Pharma Inc. | Health Care | US Equity | Common stocks | Micro cap | $65,960,467 | 30,489 | |
| LUMO | Lumos Pharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $69,651,777 | 15,931 | |
| LVTX | LAVA Therapeutics N.V. | Health Care | US Equity | Common stocks | Micro cap | $69,722,830 | 3,542 | |
| LXRX | Lexicon Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $506,807,051 | 1,592,977 | |
| LYEL | Lyell Immunopharma, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,781,864,238 | 636,011 | |
| LYRA | Lyra Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $208,135,860 | 63,367 | |
| MACK | Merrimack Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $56,323,021 | 85,744 | |
| MBIO | Mustang Bio Inc. | Health Care | US Equity | Common stocks | Micro cap | $75,434,897 | 1,113,913 | |
| MBRX | Moleculin Biotech Inc. | Health Care | US Equity | Common stocks | Micro cap | $46,582,691 | 60,719 | |
| MCRB | Seres Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $629,042,784 | 1,319,934 | |
| MDGL | Madrigal Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $1,200,829,363 | 166,842 | |
| MDNA | Medicenna Therapeutics Corp. | Health Care | US Equity | Common stocks | Micro cap | $56,304,135 | 83,339 | |
| MDWD | Mediwound Ltd. | Health Care | US Equity | Common stocks | Micro cap | $64,624,234 | 68,328 | |
| MEIP | MEI Pharma Inc | Health Care | US Equity | Common stocks | Micro cap | $69,032,796 | 1,340,322 | |
| MESO | Mesoblast ADRs | Health Care | US Equity | ADRs | Small cap | $439,707,276 | 82,615 | |
| MGNX | Macrogenics Inc | Health Care | US Equity | Common stocks | Small cap | $312,825,241 | 1,026,716 | |
| MGTA | Magenta Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $101,880,541 | 78,411 | |
| MGTX | Meiragtx Holdings Plc | Health Care | US Equity | Common stocks | Small cap | $469,015,012 | 127,150 | |
| MIGI | Mawson Infrastructure Group Inc | Health Care | US Equity | Common stocks | Micro cap | $68,296,587 | 455,099 | |
| MIRM | Mirum Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Small cap | $810,436,844 | 177,599 | |
| MIRO | Miromatrix Medical Inc. | Health Care | US Equity | Common stocks | Micro cap | $57,528,341 | 22,378 | |
| MIST | Milestone Pharmaceuticals Inc. | Health Care | US Equity | Common stocks | Micro cap | $209,475,894 | 142,862 | |
| MITO | Stealth BioTherapeutics Corp. ADRs | Health Care | US Equity | ADRs | Micro cap | $18,177,095 | 395,042 | |
| MLTX | MoonLake Immunotherapeutics - Class A | Health Care | US Equity | Common stocks | Micro cap | $213,799,450 | 118,644 | |
| MNKD | Mannkind Corp | Health Care | US Equity | Common stocks | Small cap | $1,027,941,178 | 4,329,754 | |
| MNMD | Mind Medicine (MindMed) Inc. | Health Care | US Equity | Common stocks | Small cap | $325,747,328 | 1,799,376 | |
| MNOV | Medicinova Inc | Health Care | US Equity | Common stocks | Micro cap | $119,665,520 | 15,455 | |
| MNPR | Monopar Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $23,097,513 | 8,176 | |
| MOLN | Molecular Partners AG ADRs | Health Care | US Equity | ADRs | Micro cap | $210,940,076 | 13,409 | |
| MOR | MorphoSys AG ADRs | Health Care | US Equity | ADRs | Small cap | $798,288,911 | 30,877 | |
| MORF | Morphic Holding, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,120,451,958 | 322,215 | |
| MREO | Mereo BioPharma Group plc ADRs | Health Care | US Equity | ADRs | Micro cap | $134,528,895 | 1,642,872 | |
| MRKR | Marker Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $37,494,235 | 948,843 | |
| MRNS | Marinus Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $214,300,143 | 149,857 | |
| MRSN | Mersana Therapeutics Inc. | Health Care | US Equity | Common stocks | Small cap | $723,911,643 | 833,363 | |
| MRTX | Mirati Therapeutics Inc | Health Care | US Equity | Common stocks | Mid cap | $4,467,137,255 | 1,204,772 | |
| MRUS | Merus N.V. | Health Care | US Equity | Common stocks | Small cap | $1,149,248,083 | 168,761 | |
| MRVI | Maravai LifeSciences Holdings, Inc | Health Care | US Equity | Common stocks | Mid cap | $3,522,631,613 | 1,448,575 | |
| MTCR | Metacrine, Inc. | Health Care | US Equity | Common stocks | Micro cap | $21,242,188 | 230,037 | |
| MTEM | Molecular Templates | Health Care | US Equity | Common stocks | Micro cap | $49,471,456 | 125,484 | |
| MTNB | Matinas Biopharma Holdings Inc | Health Care | US Equity | Common stocks | Micro cap | $183,619,194 | 409,552 | |
| MTP | Midatech Pharma PLC ADRs | Health Care | US Equity | ADRs | Micro cap | $14,575,056 | 50,977 | |
| MYMD | MyMD Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $189,910,643 | 289,863 | |
| MYOV | Myovant Sciences Ltd. | Health Care | US Equity | Common stocks | Small cap | $1,697,929,476 | 871,158 | |
| NAUT | Nautilus Biotechnology, Inc. | Health Care | US Equity | Common stocks | Small cap | $366,509,767 | 158,047 | |
| NAVB | Navidea Biopharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $16,497,511 | 76,730 | |
| NBIX | Neurocrine Biosciences Inc | Health Care | US Equity | Common stocks | Large cap | $10,030,651,986 | 596,105 | |
| NBRV | Nabriva Therapeutics Plc | Health Care | US Equity | Common stocks | Micro cap | $12,876,400 | 1,130,268 | |
| NBSE | NeuBase Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $36,774,869 | 44,078 | |
| NBTX | Nanobiotix S.A. - ADRs | Health Care | US Equity | ADRs | Micro cap | $146,965,180 | 3,266 | |
| NBY | Novabay Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $16,053,863 | 903,284 | |
| NCNA | NuCana plc ADRs | Health Care | US Equity | ADRs | Micro cap | $78,270,000 | 539,940 | |
| NERV | Minerva Neurosciences Inc | Health Care | US Equity | Common stocks | Micro cap | $18,103,254 | 70,693 | |
| NEXI | NexImmune, Inc. | Health Care | US Equity | Common stocks | Micro cap | $28,095,407 | 535,265 | |
| NGM | NGM Biopharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,366,220,113 | 464,886 | |
| NHWK | NightHawk Biosciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $65,059,571 | 51,392 | |
| NKTR | Nektar Therapeutics | Health Care | US Equity | Common stocks | Small cap | $927,653,621 | 2,389,094 | |
| NKTX | Nkarta, Inc. | Health Care | US Equity | Common stocks | Small cap | $514,949,666 | 479,020 | |
| NLSP | NLS Pharmaceutics Ltd. | Health Care | US Equity | Common stocks | Micro cap | $7,866,890 | 1,034,279 | |
| NMTR | 9 Meters Biopharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $68,404,348 | 2,271,661 | |
| NNVC | Nanoviricides Inc | Health Care | US Equity | Common stocks | Micro cap | $30,618,100 | 1,815,203 | |
| NOTV | Inotiv, Inc. | Health Care | US Equity | Common stocks | Small cap | $612,365,736 | 212,098 | |
| NOVN | Novan Inc | Health Care | US Equity | Common stocks | Micro cap | $55,792,222 | 244,008 | |
| NRBO | NeuroBo Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $10,664,708 | 102,391 | |
| NRIX | Nurix Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $797,830,200 | 404,651 | |
| NRSN | NeuroSense Therapeutics Ltd. | Health Care | US Equity | Common stocks | Micro cap | $21,996,503 | 251,943 | |
| NRXP | NRX Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $53,812,861 | 9,812,699 | |
| NSTG | Nanostring Technologies Inc | Health Care | US Equity | Common stocks | Small cap | $806,207,798 | 859,297 | |
| NTLA | Intellia Therapeutics Inc | Health Care | US Equity | Common stocks | Mid cap | $4,986,373,030 | 1,147,796 | |
| NTRB | Nutriband Inc. | Health Care | US Equity | Common stocks | Micro cap | $41,061,174 | 175,182 | |
| NUVB | Nuvation Bio Inc. Class A | Health Care | US Equity | Common stocks | Small cap | $600,171,825 | 1,526,554 | |
| NUVL | Nuvalent, Inc. | Health Care | US Equity | Common stocks | Small cap | $698,389,445 | 122,054 | |
| NVAX | Novavax Inc | Health Care | US Equity | Common stocks | Mid cap | $3,151,949,562 | 6,466,083 | |
| NVCT | Nuvectis Pharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $125,046,805 | 14,132 | |
| NVIV | Invivo Therapeutics Holdings Corp | Health Care | US Equity | Common stocks | Micro cap | $10,670,197 | 48,028 | |
| NVO | Novo Nordisk A/S ADRs | Health Care | US Equity | ADRs | Large cap | $189,573,537,560 | 1,754,409 | |
| NXTC | NextCure, Inc. | Health Care | US Equity | Common stocks | Micro cap | $140,123,183 | 103,273 | |
| NYMX | Nymox Pharmaceutical Corp | Health Care | US Equity | Common stocks | Micro cap | $55,431,794 | 318,922 | |
| OBSV | ObsEva SA | Health Care | US Equity | Common stocks | Micro cap | $33,563,726 | 4,376,799 | |
| OCGN | Ocugen, Inc. | Health Care | US Equity | Common stocks | Small cap | $580,396,655 | 4,822,384 | |
| OCUL | Ocular Therapeutix Inc | Health Care | US Equity | Common stocks | Small cap | $420,239,214 | 391,022 | |
| OCUP | Ocuphire Pharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $54,026,584 | 78,638 | |
| OCX | Oncocyte Corp | Health Care | US Equity | Common stocks | Micro cap | $115,882,032 | 196,548 | |
| OGEN | Oragenics Inc | Health Care | US Equity | Common stocks | Micro cap | $43,066,078 | 279,094 | |
| OLMA | Olema Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $155,615,302 | 811,879 | |
| OMER | Omeros Corp | Health Care | US Equity | Common stocks | Small cap | $451,656,108 | 731,808 | |
| OMGA | Omega Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $223,475,457 | 60,030 | |
| ONCR | Oncorus, Inc. | Health Care | US Equity | Common stocks | Micro cap | $37,790,674 | 48,467 | |
| ONCS | Oncosec Medical Inc | Health Care | US Equity | Common stocks | Micro cap | $29,248,598 | 18,991 | |
| ONCT | Oncternal Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $60,129,457 | 411,931 | |
| ONCY | Oncolytics Biotech Inc. | Health Care | US Equity | Common stocks | Micro cap | $75,227,577 | 101,892 | |
| ONTX | Onconova Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $27,531,994 | 148,465 | |
| OPNT | Opiant Pharmaceuticals Inc. | Health Care | US Equity | Common stocks | Micro cap | $63,901,431 | 20,579 | |
| OPT | Opthea Limited ADRs | Health Care | US Equity | ADRs | Small cap | $321,779,387 | 1,848 | |
| ORGS | Orgenesis Inc. | Health Care | US Equity | Common stocks | Micro cap | $41,202,455 | 27,947 | |
| ORIC | Oric Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $182,784,122 | 131,499 | |
| ORMP | Oramed Pharmaceuticals Inc. | Health Care | US Equity | Common stocks | Small cap | $370,410,353 | 627,574 | |
| ORTX | Orchard Therapeutics plc ADRs | Health Care | US Equity | ADRs | Micro cap | $75,874,987 | 731,736 | |
| OTIC | Otonomy Inc | Health Care | US Equity | Common stocks | Micro cap | $21,143,425 | 2,645,230 | |
| OTLK | Outlook Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $260,066,329 | 473,181 | |
| OVID | Ovid Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $156,331,041 | 72,587 | |
| OYST | Oyster Point Pharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $212,287,962 | 134,958 | |
| PALI | Palisade Bio, Inc. | Health Care | US Equity | Common stocks | Micro cap | $7,329,857 | 176,403 | |
| PASG | Passage Bio, Inc. | Health Care | US Equity | Common stocks | Micro cap | $110,560,367 | 204,767 | |
| PBLA | Panbela Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $28,460,442 | 19,999 | |
| PBYI | Puma Biotechnology Inc | Health Care | US Equity | Common stocks | Micro cap | $161,723,669 | 235,857 | |
| PCSA | Processa Pharmaceuticals Inc. | Health Care | US Equity | Common stocks | Micro cap | $49,809,016 | 13,737 | |
| PCVX | Vaxcyte, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,504,231,798 | 248,558 | |
| PDSB | PDS Biotechnology Corporation | Health Care | US Equity | Common stocks | Micro cap | $150,546,460 | 303,693 | |
| PEPG | PepGen Inc. | Health Care | US Equity | Common stocks | Micro cap | $264,677,549 | 43,097 | |
| PGEN | Precigen, Inc. | Health Care | US Equity | Common stocks | Small cap | $482,908,049 | 1,110,101 | |
| PHAR | Pharming Group N.V. ADRs | Health Care | US Equity | ADRs | Small cap | $701,106,706 | 1,785 | |
| PHAS | Phasebio Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $58,915,614 | 211,088 | |
| PHAT | Phathom Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Small cap | $358,061,374 | 124,819 | |
| PHGE | BiomX Inc. | Health Care | US Equity | Common stocks | Micro cap | $23,062,371 | 837,533 | |
| PHGE= | BiomX Inc - Units (1 Ord & 1 War) | Health Care | US Equity | Units | Micro cap | $23,062,371 | 186,248 | |
| PHIO | Phio Pharmaceuticals Corp. | Health Care | US Equity | Common stocks | Micro cap | $10,488,533 | 119,547 | |
| PHVS | Pharvaris N.V. | Health Care | US Equity | Common stocks | Small cap | $564,245,015 | 6,389 | |
| PIRS | Pieris Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $116,073,755 | 180,313 | |
| PLRX | Pliant Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $999,440,680 | 755,012 | |
| PLX | Protalix Biotherapeutics Inc. (De) | Health Care | US Equity | Common stocks | Micro cap | $57,887,859 | 137,566 | |
| PMCB | PharmaCyte Biotech Inc. | Health Care | US Equity | Common stocks | Micro cap | $54,985,025 | 201,238 | |
| PMVP | PMV Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Small cap | $738,173,830 | 561,272 | |
| PNT | POINT Biopharma Global Inc. | Health Care | US Equity | Common stocks | Small cap | $730,913,442 | 379,270 | |
| PPBT | Purple Biotech Ltd. ADRs | Health Care | US Equity | ADRs | Micro cap | $47,266,707 | 49,960 | |
| PRAX | Praxis Precision Medicines, Inc. | Health Care | US Equity | Common stocks | Micro cap | $193,242,783 | 666,121 | |
| PRDS | Pardes Biosciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $184,469,935 | 135,226 | |
| PRLD | Prelude Therapeutics Incorporated | Health Care | US Equity | Common stocks | Small cap | $397,494,781 | 113,769 | |
| PRQR | ProQR Therapeutics N.V. | Health Care | US Equity | Common stocks | Micro cap | $58,102,006 | 347,353 | |
| PRTA | Prothena Plc | Health Care | US Equity | Common stocks | Small cap | $1,467,745,966 | 278,088 | |
| PRTC | PureTech Health plc ADRs | Health Care | US Equity | ADRs | Small cap | $877,288,377 | 4,981 | |
| PRTG | Portage Biotech Inc. | Health Care | US Equity | Common stocks | Micro cap | $135,388,816 | 19,774 | |
| PRTK | Paratek Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $140,448,005 | 317,284 | |
| PRVB | Provention Bio Inc | Health Care | US Equity | Common stocks | Small cap | $430,583,615 | 501,121 | |
| PSTI | Pluristem Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $32,347,584 | 87,409 | |
| PSTV | Plus Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $11,871,493 | 73,736 | |
| PSTX | Poseida Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $352,345,064 | 5,108,863 | |
| PTCT | PTC Therapeutics Inc | Health Care | US Equity | Common stocks | Mid cap | $3,720,845,590 | 473,332 | |
| PTE | PolarityTE, Inc. | Health Care | US Equity | Common stocks | Micro cap | $7,232,200 | 100,951 | |
| PTGX | Protagonist Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $510,474,307 | 1,074,597 | |
| PTIX | Protagenic Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $10,606,236 | 19,398 | |
| PTN | Palatin Technologies Inc | Health Care | US Equity | Common stocks | Micro cap | $66,102,661 | 701,898 | |
| PTPI | Petros Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $15,927,237 | 3,635,434 | |
| PULM | Pulmatrix Inc | Health Care | US Equity | Common stocks | Micro cap | $16,597,143 | 32,976 | |
| PYPD | PolyPid Ltd. | Health Care | US Equity | Common stocks | Micro cap | $112,539,420 | 25,700 | |
| PYXS | Pyxis Oncology, Inc. | Health Care | US Equity | Common stocks | Micro cap | $95,497,650 | 41,902 | |
| QLGN | Qualigen Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $16,488,105 | 269,715 | |
| QNRX | Quoin Pharmaceuticals, Ltd. ADRs | Health Care | US Equity | ADRs | Micro cap | $48,366,941 | 3,060,927 | |
| QSI | Quantum-Si Incorporated - Class A | Health Care | US Equity | Common stocks | Small cap | $478,926,735 | 572,054 | |
| QURE | Uniqure Nv | Health Care | US Equity | Common stocks | Small cap | $920,095,526 | 793,775 | |
| RAIN | Rain Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $144,402,493 | 105,438 | |
| RANI | Rani Therapeutics Holdings, Inc. | Health Care | US Equity | Common stocks | Micro cap | $201,569,292 | 30,264 | |
| RAPT | RAPT Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $722,196,560 | 218,147 | |
| RARE | Ultragenyx Pharmaceutical Inc | Health Care | US Equity | Common stocks | Mid cap | $3,589,389,485 | 1,065,443 | |
| RCKT | Rocket Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $1,081,716,598 | 699,188 | |
| RCOR | Renovacor, Inc. | Health Care | US Equity | Common stocks | Micro cap | $31,340,857 | 12,068 | |
| RCUS | Arcus Biosciences Inc | Health Care | US Equity | Common stocks | Small cap | $1,867,499,817 | 642,782 | |
| REGN | Regeneron Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Large cap | $66,875,950,806 | 603,215 | |
| REPL | Replimune Group Inc | Health Care | US Equity | Common stocks | Small cap | $976,273,333 | 148,492 | |
| RETA | Reata Pharmaceuticals Inc Class A | Health Care | US Equity | Common stocks | Small cap | $661,984,103 | 235,784 | |
| REVB | Revelation Biosciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $12,167,008 | 11,652,865 | |
| REVBU | Revelation Biosciences Inc - Units (1 Ord share & 1 War) | Health Care | US Equity | Units | Micro cap | $12,167,008 | 749,625 | |
| RFL | Rafael Holdings Inc Class B | Real Estate | US Equity | Common stocks | Micro cap | $42,434,796 | 148,324 | |
| RGLS | Regulus Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $240,868,947 | 85,967 | |
| RGNX | Regenxbio Inc | Health Care | US Equity | Common stocks | Small cap | $1,431,776,640 | 353,908 | |
| RIGL | Rigel Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $241,970,870 | 3,916,542 | |
| RLAY | Relay Therapeutics, Inc. | Health Care | US Equity | Common stocks | Mid cap | $2,142,025,293 | 813,321 | |
| RLYB | Rallybio Corp | Health Care | US Equity | Common stocks | Small cap | $342,848,120 | 35,199 | |
| RNA | Avidity Biosciences, Inc. | Health Care | US Equity | Common stocks | Small cap | $991,456,149 | 229,623 | |
| RNAZ | TransCode Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $17,649,038 | 17,632 | |
| RNXT | RenovoRx, Inc. | Health Care | US Equity | Common stocks | Micro cap | $20,944,454 | 14,009 | |
| ROIV | Roivant Sciences Ltd. | Health Care | US Equity | Common stocks | Mid cap | $3,136,347,704 | 662,490 | |
| RPHM | Reneo Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $67,563,823 | 99,592 | |
| RPRX | Royalty Pharma plc - Class A | Health Care | US Equity | Common stocks | Large cap | $19,102,982,079 | 2,049,865 | |
| RPTX | Repare Therapeutics Inc. | Health Care | US Equity | Common stocks | Small cap | $500,147,021 | 198,876 | |
| RUBY | Rubius Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $68,499,666 | 406,119 | |
| RVLP | RVL Pharmaceuticals plc | Health Care | US Equity | Common stocks | Micro cap | $165,428,325 | 45,020 | |
| RVMD | Revolution Medicines, Inc. | Health Care | US Equity | Common stocks | Mid cap | $2,230,148,976 | 1,450,422 | |
| RVNC | Revance Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $1,644,147,036 | 497,669 | |
| RVPH | Reviva Pharmaceuticals Holdings, Inc. | Health Care | US Equity | Common stocks | Micro cap | $10,744,633 | 545,324 | |
| RXDX | Prometheus Biosciences, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,979,349,302 | 491,714 | |
| RXRX | Recursion Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,972,563,250 | 817,013 | |
| RYTM | Rhythm Pharmaceuticals | Health Care | US Equity | Common stocks | Small cap | $1,105,708,426 | 3,808,698 | |
| RZLT | Rezolute Inc. | Health Care | US Equity | Common stocks | Micro cap | $103,099,291 | 11,674 | |
| SABS | SAB Biotherapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $48,194,591 | 30,015 | |
| SAGE | Sage Therapeutics Inc | Health Care | US Equity | Common stocks | Mid cap | $2,554,566,526 | 430,277 | |
| SANA | Sana Biotechnology, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,599,848,664 | 1,196,838 | |
| SAVA | Cassava Sciences, Inc. | Health Care | US Equity | Common stocks | Small cap | $818,799,465 | 2,376,756 | |
| SBTX | Silverback Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $180,207,112 | 713,906 | |
| SCPH | scPharmaceuticals Inc. | Health Care | US Equity | Common stocks | Micro cap | $168,523,044 | 35,702 | |
| SCPS | Scopus Biopharma Inc. | Health Care | US Equity | Common stocks | Micro cap | $9,492,419 | 55,812 | |
| SEEL | Seelos Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $100,775,625 | 646,374 | |
| SEER | Seer, Inc. - Class A | Health Care | US Equity | Common stocks | Small cap | $697,527,456 | 245,657 | |
| SELB | Selecta Biosciences Inc | Health Care | US Equity | Common stocks | Small cap | $375,674,499 | 1,386,669 | |
| SESN | Sesen Bio Inc | Health Care | US Equity | Common stocks | Micro cap | $139,644,498 | 3,737,426 | |
| SGEN | Seattle Genetics Inc | Health Care | US Equity | Common stocks | Large cap | $31,379,848,484 | 956,656 | |
| SGMO | Sangamo Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $990,981,167 | 1,318,323 | |
| SGTX | Sigilon Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $23,651,458 | 46,161 | |
| SIGA | Siga Technologies Inc | Health Care | US Equity | Common stocks | Small cap | $1,807,347,638 | 23,596,627 | |
| SIOX | Sio Gene Therapies Inc. | Health Care | US Equity | Common stocks | Micro cap | $25,343,902 | 160,955 | |
| SLGL | Sol-Gel Technologies Ltd. | Health Care | US Equity | Common stocks | Micro cap | $138,529,556 | 11,907 | |
| SLN | Silence Therapeutics Plc ADRs | Health Care | US Equity | ADRs | Micro cap | $293,596,034 | 51,427 | |
| SLRX | Salarius Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $13,355,666 | 301,569 | |
| SLS | Sellas Life Sciences Group Inc | Health Care | US Equity | Common stocks | Micro cap | $63,710,946 | 87,175 | |
| SMMT | Summit Therapeutics PLC ADRs | Health Care | US Equity | ADRs | Micro cap | $104,009,697 | 52,440 | |
| SNDX | Syndax Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $1,357,563,960 | 559,957 | |
| SNGX | Soligenix, Inc. | Health Care | US Equity | Common stocks | Micro cap | $38,108,077 | 396,887 | |
| SNPX | Synaptogenix, Inc | Health Care | US Equity | Common stocks | Micro cap | $50,757,467 | 129,284 | |
| SNSE | Sensei Biotherapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $67,891,843 | 31,918 | |
| SONN | Sonnet BioTherapeutics Holdings, Inc. | Health Care | US Equity | Common stocks | Micro cap | $18,055,196 | 387,225 | |
| SPPI | Spectrum Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $244,918,618 | 1,203,550 | |
| SPRB | Spruce Biosciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $47,120,500 | 29,356 | |
| SPRC | SciSparc Ltd. | Health Care | US Equity | Common stocks | Micro cap | $7,546,269 | 42,081 | |
| SPRO | Spero Therapeutics | Health Care | US Equity | Common stocks | Micro cap | $27,352,632 | 185,498 | |
| SQZ | SQZ Biotechnologies Company | Health Care | US Equity | Common stocks | Micro cap | $99,445,080 | 64,975 | |
| SRNE | Sorrento Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $1,022,929,171 | 9,294,435 | |
| SRPT | Sarepta Therapeutics Inc | Health Care | US Equity | Common stocks | Mid cap | $9,544,896,413 | 1,001,167 | |
| SRRA | Sierra Oncology | Health Care | US Equity | Common stocks | Small cap | $1,336,962,176 | 858,299 | |
| SRRK | Scholar Rock Holding Corp | Health Care | US Equity | Common stocks | Small cap | $583,539,345 | 430,390 | |
| SRZN | Surrozen, Inc. | Health Care | US Equity | Common stocks | Micro cap | $101,859,815 | 8,438 | |
| STAB | Statera Biopharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $9,373,764 | 587,341 | |
| STOK | Stoke Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $851,457,161 | 226,402 | |
| STRO | Sutro Biopharma, Inc. | Health Care | US Equity | Common stocks | Small cap | $369,824,688 | 454,867 | |
| STSA | Satsuma Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $189,367,021 | 15,560 | |
| STTK | Shattuck Labs, Inc. | Health Care | US Equity | Common stocks | Micro cap | $159,780,189 | 72,953 | |
| SURF | Surface Oncology Inc | Health Care | US Equity | Common stocks | Micro cap | $112,005,684 | 498,353 | |
| SVA | Sinovac Biotech, Ltd. | Health Care | US Equity | Common stocks | Small cap | $643,779,512 | 0 | |
| SVRA | Savara Inc | Health Care | US Equity | Common stocks | Micro cap | $195,012,918 | 156,209 | |
| SWTX | SpringWorks Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,443,231,304 | 572,920 | |
| SYBX | Synlogic | Health Care | US Equity | Common stocks | Micro cap | $79,359,439 | 105,043 | |
| SYN | Synthetic Biologics Inc | Health Care | US Equity | Common stocks | Micro cap | $23,290,770 | 441,763 | |
| SYRS | Syros Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $60,176,357 | 898,654 | |
| TALS | Talaris Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $201,099,343 | 204,269 | |
| TARA | ArTara Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $39,548,535 | 16,824 | |
| TARS | Tarsus Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Small cap | $493,181,658 | 72,264 | |
| TBPH | Theravance Biopharma Inc | Health Care | US Equity | Common stocks | Small cap | $723,001,728 | 916,525 | |
| TCBP | TC BioPharm (Holdings) plc ADRs | Health Care | US Equity | Common stocks | Micro cap | $15,537,688 | 618,559 | |
| TCON | Tracon Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $43,272,032 | 41,318 | |
| TCRR | TCR2 Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $142,843,769 | 215,454 | |
| TCRT | Alaunos Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $356,318,426 | 1,538,554 | |
| TCRX | TScan Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $66,254,419 | 20,924 | |
| TECH | Bio-Techne Corp | Health Care | US Equity | Common stocks | Large cap | $14,895,002,451 | 196,460 | |
| TENX | Oxygen Biotherapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $7,587,281 | 153,464 | |
| TERN | Terns Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $61,126,828 | 54,805 | |
| TFFP | TFF Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $156,556,457 | 75,803 | |
| TGTX | TG Therapeutics Inc | Health Care | US Equity | Common stocks | Small cap | $1,092,460,841 | 2,380,449 | |
| THRX | Theseus Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Small cap | $301,880,670 | 49,314 | |
| TIL | Instil Bio, Inc. | Health Care | US Equity | Common stocks | Small cap | $879,195,827 | 220,776 | |
| TLSA | Tiziana Life Sciences plc ADRs | Health Care | US Equity | ADRs | Micro cap | $73,135,146 | 29,821 | |
| TMBR | Timber Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $9,563,075 | 24,077,462 | |
| TNGX | Tango Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $449,011,160 | 272,526 | |
| TNXP | Tonix Pharmaceuticals Holding Corp | Health Care | US Equity | Common stocks | Micro cap | $58,993,660 | 19,734,538 | |
| TNYA | Tenaya Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $225,851,005 | 161,679 | |
| TPST | Tempest Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $23,742,914 | 13,131 | |
| TPTX | Turning Point Therapeutics, Inc. | Health Care | US Equity | Common stocks | Mid cap | $3,755,570,775 | 772,003 | |
| TRDA | Entrada Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $398,342,701 | 88,360 | |
| TRVI | Trevi Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $175,787,071 | 306,765 | |
| TRVN | Trevena Inc | Health Care | US Equity | Common stocks | Micro cap | $44,219,204 | 1,006,244 | |
| TSHA | Taysha Gene Therapies, Inc. | Health Care | US Equity | Common stocks | Micro cap | $168,481,952 | 91,685 | |
| TTNP | Titan Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $20,334,612 | 129,121 | |
| TVTX | Travere Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,752,355,454 | 696,608 | |
| TYME | Tyme Technologies Inc | Health Care | US Equity | Common stocks | Micro cap | $58,808,654 | 931,748 | |
| TYRA | Tyra Biosciences, Inc. | Health Care | US Equity | Common stocks | Small cap | $518,674,961 | 42,640 | |
| UBX | Unity Biotechnology Inc | Health Care | US Equity | Common stocks | Micro cap | $90,611,310 | 289,232 | |
| UNCY | Unicycive Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $10,967,807 | 23,080 | |
| UPC | Universe Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $13,437,900 | 27,273 | |
| URGN | UroGen Pharma Ltd. | Health Care | US Equity | Common stocks | Micro cap | $193,976,687 | 49,859 | |
| UTHR | United Therapeutics Corp | Health Care | US Equity | Common stocks | Mid cap | $9,881,588,513 | 444,024 | |
| VACC | Vaccitech plc ADRs | Health Care | US Equity | ADRs | Micro cap | $174,137,273 | 3,035 | |
| VALN | Valneva SE - ADRs | Health Care | US Equity | ADRs | Small cap | $1,206,752,873 | 12,601 | |
| VAXX | Vaxxinity, Inc. | Health Care | US Equity | Common stocks | Micro cap | $266,916,298 | 284,296 | |
| VBIV | VBI Vaccines Inc | Health Care | US Equity | Common stocks | Small cap | $315,074,143 | 1,033,969 | |
| VBLT | Vascular Biogenics Ltd. | Health Care | US Equity | Common stocks | Micro cap | $16,645,401 | 10,866,213 | |
| VCEL | Vericel Corp | Health Care | US Equity | Common stocks | Small cap | $1,327,116,409 | 381,652 | |
| VCNX | Vaccinex, Inc. | Health Care | US Equity | Common stocks | Micro cap | $46,930,456 | 67,914 | |
| VCYT | Veracyte Inc | Health Care | US Equity | Common stocks | Small cap | $1,864,552,664 | 964,765 | |
| VECT | VectivBio Holding AG | Health Care | US Equity | Common stocks | Micro cap | $204,227,844 | 7,934 | |
| VERA | Vera Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $550,310,317 | 53,685 | |
| VERV | Verve Therapeutics, Inc. | Health Care | US Equity | Common stocks | Mid cap | $2,133,347,845 | 2,031,082 | |
| VIGL | Vigil Neuroscience, Inc. | Health Care | US Equity | Common stocks | Micro cap | $223,885,182 | 38,835 | |
| VINC | Vincera Pharma, Inc. | Health Care | US Equity | Common stocks | Micro cap | $33,479,835 | 85,603 | |
| VIR | Vir Biotechnology, Inc. | Health Care | US Equity | Common stocks | Mid cap | $3,793,443,311 | 592,487 | |
| VIRI | Virios Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $72,474,393 | 19,425 | |
| VIRX | Viracta Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $156,993,397 | 95,428 | |
| VKTX | Viking Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $288,348,677 | 1,224,970 | |
| VLON | Vallon Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $4,457,442 | 776,501 | |
| VNDA | Vanda Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Small cap | $588,804,819 | 331,236 | |
| VOR | Vor Biopharma Inc. | Health Care | US Equity | Common stocks | Micro cap | $205,504,052 | 62,686 | |
| VRCA | Verrica Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $166,019,974 | 164,255 | |
| VRDN | Viridian Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $411,370,941 | 297,653 | |
| VRNA | Verona Pharma plc ADRs | Health Care | US Equity | ADRs | Small cap | $828,367,197 | 75,519 | |
| VRPX | Virpax Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $18,977,855 | 36,944 | |
| VRTX | Vertex Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Large cap | $75,532,446,639 | 1,325,928 | |
| VSTM | Verastem Inc | Health Care | US Equity | Common stocks | Micro cap | $238,515,611 | 819,393 | |
| VTGN | Vistagen Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $32,556,041 | 35,288,185 | |
| VTVT | vTv Therapeutics Inc Class A | Health Care | US Equity | Common stocks | Micro cap | $86,356,182 | 515,849 | |
| VTYX | Ventyx Biosciences, Inc. | Health Care | US Equity | Common stocks | Small cap | $928,526,423 | 139,088 | |
| VXRT | Vaxart Inc | Health Care | US Equity | Common stocks | Small cap | $526,266,245 | 2,534,695 | |
| VYGR | Voyager Therapeutics Inc | Health Care | US Equity | Common stocks | Micro cap | $234,590,883 | 140,900 | |
| VYNE | VYNE Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $18,270,128 | 141,216 | |
| VYNT | Vyant Bio, Inc. | Health Care | US Equity | Common stocks | Micro cap | $24,118,494 | 18,081 | |
| WINT | Windtree Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $12,159,268 | 194,667 | |
| WVE | Wave Life Sciences Ltd | Health Care | US Equity | Common stocks | Small cap | $303,870,389 | 255,086 | |
| XBIO | Xenetic Biosciences, Inc. | Health Care | US Equity | Common stocks | Micro cap | $13,202,765 | 64,226 | |
| XBIT | Xbiotech Inc | Health Care | US Equity | Common stocks | Micro cap | $156,457,874 | 45,872 | |
| XCUR | Exicure, Inc. | Health Care | US Equity | Common stocks | Micro cap | $11,313,887 | 561,291 | |
| XENE | Xenon Pharmaceuticals Inc. | Health Care | US Equity | Common stocks | Mid cap | $2,359,162,613 | 285,471 | |
| XERS | Xeris Pharmaceuticals Inc | Health Care | US Equity | Common stocks | Micro cap | $254,240,114 | 776,955 | |
| XFOR | X4 Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Micro cap | $97,477,417 | 244,222 | |
| XLO | Xilio Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $67,580,153 | 46,504 | |
| XNCR | Xencor Inc | Health Care | US Equity | Common stocks | Small cap | $1,819,002,570 | 277,520 | |
| XOMA | Xoma Corp | Health Care | US Equity | Common stocks | Micro cap | $229,932,526 | 29,866 | |
| XRTX | XORTX Therapeutics Inc. | Health Care | US Equity | Common stocks | Micro cap | $18,835,046 | 61,437 | |
| XTLB | XTL Biopharmaceuticals ADRs | Health Care | US Equity | ADRs | Micro cap | $9,590,349 | 6,360 | |
| YMAB | Y-Mabs Therapeutics, Inc. | Health Care | US Equity | Common stocks | Small cap | $800,067,747 | 222,085 | |
| YMTX | Yumanity Therapeutics, Inc. | Health Care | US Equity | Common stocks | Micro cap | $17,913,171 | 40,603 | |
| ZEAL | Zealand Pharma A/S ADRs | Health Care | US Equity | ADRs | Small cap | $753,729,462 | 3,368 | |
| ZIVO | Zivo Bioscience Inc. | Consumer Staples | US Equity | Common stocks | Micro cap | $36,454,084 | 5,801 | |
| ZLAB | Zai Lab Limited ADRs | Health Care | US Equity | ADRs | Mid cap | $4,324,629,178 | 489,856 | |
| ZNTL | Zentalis Pharmaceuticals, Inc. | Health Care | US Equity | Common stocks | Small cap | $1,624,603,605 | 453,618 | |
| ZSAN | Zosano Pharma Corp | Health Care | US Equity | Common stocks | Micro cap | $10,294,746 | 1,154,951 | |
| ZYME | Zymeworks Inc. | Health Care | US Equity | Common stocks | Small cap | $430,143,393 | 820,410 | |
| TOTAL | 759 |
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